The aim of this application of genomics in infectious diseases module is to provide the student with a critical understanding of how microbial genomes (viral, bacterial and eukaryotic) can be used to provide more accurate diagnosis, predict which drugs are likely to be most effective, to monitor treatment and to control infectious disease in individuals and populations.
These aims specifically reflect the following:
- The increasing availability and use of microbial genome for diagnosis and treatment.
- Key factors for treating microbial infections is the identification of the infective agents, the carriage of specific virulence factors and potential resistance to chemotherapeutic drugs.
- The possession of the genome sequences of an epidemic strains provides tools for determining the source of an infection and the ability to control it.
- Genomics is having a major impact on the development of novel diagnostic tools (e.g. point of need, rapid).
Outline Of Syllabus
This module will cover:
- Infection as a cause of national and global morbidity and mortality
- Transmission of human infections: person to person, food and waterborne, sexually transmitted, vector-borne
- Prokaryote, eukaryote and viral microbes: their genomes, replication and population genetics
- Genomic characterisation of viruses: DNA and RNA genomes, single-stranded, double stranded, segmented
- Genomic comparisons of microbes in the context of outbreaks and transmissions in hospitals and the community
- Anti-infective drug action
- Genome plasticity – mutation, horizontal and vertical gene flow and genetic drift – in the context of vaccinology and drug resistance
- Genomic evidence of individual susceptibility to specific infections
- Role of genomics in infectious disease diagnosis, prognosis, drug selection, resistance, monitoring, epidemic control, drug research.