Description
This module introduces the structure and variation in human genomics, the fundamental principles of genetics and genomics, and the architecture of the human genome, including the functional units embedded in it.
Explore DNA sequence variation, how variation arises and its extent in populations, for example information produced by the HapMap project, designed to find genetic variants affecting health, disease and responses to drugs and environmental factors.
Learn from leading experts in genomics about:
- Aspects of gene regulation and chromatin structure, and the importance of genotype to phenotype correlation.
- DNA replication, transcription and translation, cell division (mitosis, meiosis) and recombination.
- Gene regulation: enhancers, promoters, transcription factors, silencers and the role of epigenetics.
- DNA sequence variation, type and frequency, for example single nucleotide variants (SNVs), small insertions and deletions (indels), copy number variation (CNVs), rearrangements and tandem repeats.
- Mutational mechanisms: how different types of DNA variants, including epigenetics and imprinting, affect gene function or expression to cause disease.
- Correlation of genotype with phenotype, including penetrance and variation in expression.
- Concepts of heterogeneity and pleiotropy.
- Modes of inheritance for clinical manifestation of human variation.
Learning outcomes
By the end of this module you will be able to:
- Explain core elements of genome architecture, including the properties of DNA and chromatin structure.
- Critically evaluate the regulation of gene expression, transcription and translation.
- Interpret variation in genome structure and sequence in the context of physiological function and disease and across human populations.
- Describe the correlation between genotype and phenotype.
Funding rules
Funding covers course fees only and is limited to NHS healthcare professionals working in England on a permanent contract from the full range of professional backgrounds and groups (such as medicine, nursing, healthcare scientists and technologists). Please note funding can only be allocated to those who are post registration professionals.
University entry requirements may include criteria around existing understanding and minimum English language requirements.
The Genomics Education Programme provides limited funding to the Universities listed below. Please check with your preferred university to obtain details of the programme modules and entry criteria. See below for the key steps in the application process:
Click here to view the application process for CPPD module(s) or postgraduate certificate
Click here to view the application process for extending a PGcert to a PGdip, or a PGdip to a Master’s degree
FAQs
Are applications for funding still open during the Covid-19 pandemic?
Yes. Many of our partner universities are running modules online and funding is available. Please contact your chosen university to discuss your options. You must meet the Health Education England Genomics Education Programme eligibility criteria to receive funding for modules.
I have previously applied and received funding for two modules, but would like to complete two more. Is it possible to transfer my studies to another university?
Yes. You will need to speak to your chosen university re your requirements. You must also meet the HEE GEP eligibility criteria for funding.
I have previously applied and received funding for two modules, but would like to complete two more. Is it possible to obtain funding?
Yes. You will need to speak to your chosen university re your requirements. You must also meet the HEE GEP eligibility criteria for funding
I have been awarded funding and started the programme, but I am unable to complete. What are my options?
Funding is awarded for the period specified in the application form and there is no automatic ability to defer completion of the programme. You should speak to your university in the first instance about your situation and also contact the Genomics Education Programme (GEP) team regarding funding.
You may choose to reduce the workload of your programme by switching from, for example, a full Master’s degree to a diploma or certificate. Again, you would need to contact your course provider and the GEP.
How much study time is required to undertake this programme?
Study time will vary across the course providers. You are advised to visit your preferred university’s website for more information or to contact the relevant course lead. Most modules involve around 5 days of face-to-face teaching, followed by 2-4 weeks of independent study and assessment preparation. However, distance learning options are available for most universities.
Can I build up my CPPD modules to a full Master’s, PGDip or PGCert qualification?
Funding is allocated on an individual module basis only. Candidates who meet the HEE Genomics Education Programme eligibility criteria for funding can apply for up to four funded modules in the first instance. If you wish to progress to a full Master’s or PGDip, you should discuss options with your chosen university.
I am eligible but have been refused a commissioned place – why?
This may be due to the following potential reasons:
- The university you have applied to has used up all its commissioned allocations.
- The total number of available national commissions have been fully allocated.
- We are now applying controls to the commissioned places based on healthcare profession roles to help ensure equitable access across professions on a national scale.
I am not eligible for a HEE-funded place – can I self-fund?
This should be discussed with your preferred university.
I work for an organisation that provides services to the NHS – am I eligible to apply?
Yes – please provide details of your organisation and its services for the NHS when you apply to your preferred university.
