Use in clinical context
Deletions of sections of the genome can vary in size and have a range of effects. The size of deletion, however, does not necessarily correspond to the size of the effect. A single base deletion within a gene can put out the entire reading frame and change every amino acid in the protein, and potentially causing it to be much shorter than it should be. Deletion of a large section of the genome that is not protein coding could have effects but may not have as dramatic results as a single base pair deletion within a gene.