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Definition

Where sections of the genome have been removed, this can be short sections only a few bases long, or large tracts several kilobases long.

Use in clinical context

Deletions of sections of the genome can vary in size and have a range of effects. The size of deletion, however, does not necessarily correspond to the size of the effect. A single base deletion within a gene can put out the entire reading frame and change every amino acid in the protein, and potentially causing it to be much shorter than it should be. Deletion of a large section of the genome that is not protein coding could have effects but may not have as dramatic results as a single base pair deletion within a gene.

Related terms

Amino acids | Bases | Gene | Genome | Megabase | Protein

Last updated on 31st May, 2019