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The order of the four nitrogenous bases in DNA or RNA.

Use in clinical context

The sequence of bases in a gene determines the order of amino acids in a protein. Changes to the sequence of bases can alter the amino acids and the resulting protein function. This can result in changes to the individual such as differences in hair or eye colour or the development of health conditions. Sequencing is the technique used to ‘read’ the sequence of bases in a stretch of DNA.

Last updated on 31st May, 2019