Use in clinical context
RNA is crucial for protein production. As DNA cannot leave the nucleus the relevant sections are transcribed into messenger RNA (mRNA) and transported to the ribosomes where proteins are produced. At the ribosome, transfer RNA (tRNA) facilitates the addition of the correct amino acids to the polypeptide chain which ultimately becomes the protein. The ribosomes themselves are formed of proteins and ribosomal RNA (rRNA).
An additional type of RNA, known as signal recognition particle RNA (SRP RNA), is involved in the control of translation and sorting of membrane and secreted proteins.
By sequencing RNA, it is possible to establish which genes are actively producing proteins and which are not. This can be useful in identifying aberrant gene activity and potential drug targets to inhibit or enhance gene activity to alter gene expression.