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Two chromosomes in a pair – normally one inherited from the mother and one from the father. For example, the two copies of Chromosome 1 in a cell would be referred to as homologous chromosomes.

Use in clinical context

The chromosomes in each homologous pair each have the same genes in the same order, but there will be variation between them. Some variants might have functional implications while others don’t. In many cases if the copy of a gene on one chromosome does not produce a functional protein, the copy of the gene on the other chromosome is able to produce the required protein.


Last updated on 4th December, 2020