Use in clinical context
Often when analysing whole exome and whole genome data, virtual gene panels relevant to the individual’s condition are applied, similar to panel testing. This increases the chance that identified variants are relevant to the individual’s condition and reduces computational requirements.
Panels do not always identify variants associated with an individual’s condition, however, and it may not always be clear which gene panels are relevant. In these cases, gene agnostic analysis of the entire dataset may be performed.