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Definition

Either of the two full-length DNA molecules produced by the replication of a chromosome. Following DNA replication, each chromosome is made up of two chromatids, known as ‘sister chromatids’.

Use in clinical context

The formation of chromatids is an important step in cell division ensuring that each new daughter cell has the correct complement of DNA at the end of cell division. The swapping of genetic information between non-sister chromatids occurs during meiosis, which is a method of ensuring genetic diversity. However, this can also result in the exchange of variants that may have clinical implications.

Last updated on 24th May, 2019