Use in clinical context
When cells divide by mitosis two genetically identical, therefore clonal, daughter cells are produced. Cells in a person’s body are usually clonal and populations of bacteria and viruses are also often clonal. When genomic variants arise within a cell lineage or populations of bacteria or viruses, these are no longer clonal. However, if those cells then divide a new clonal population will be created. Cancer cells can be classed as clonal. Identification of variants within a population of cancer cells can inform the diagnosis, prognosis or treatment of the disease.