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Definition

A chromosome where the centromere is not central and is located near the end of the chromosome.

Use in clinical context

Robertsonian translocations involve the swapping of the short arm of one acrocentric chromosome with the long arm of a different acrocentric chromosome. While this may not result in an altered phenotype because the individual still has copies of all genes, it can have phenotypic consequences for their offspring who may lack or have additional copies of genes.

Last updated on 8th October, 2019