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An enzyme that ’sticks’ DNA fragments together. Involved in DNA repair and replication.

Use in clinical context

DNA repair and replication are essential to the growth and maintenance of the body. There are several enzymes involved in the process, including four DNA ligases. Errors in these ligases can have important implications for DNA repair and replication. For example, the genetic condition LIG4 syndrome is caused by variants in the LIG4 gene, which codes for a ligase involved in the repair of DNA breaks. People with LIG4 syndrome often have a variety of clinical presentations, including immunodeficiency and growth and/or development delay.

Last updated on 24th May, 2019