Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a heterogeneous disease with manifestations ranging from mild autonomous cortisol secretion to overt Cushing syndrome. PBMAH can occur as an isolated endocrinopathy or as part of a genetic familial syndrome (up to 50% of cases).

Carney complex is a fully penetrant multiple endocrine neoplasia syndrome affecting the skin, heart and gonadal, adrenal and pituitary glands.